Article

Structural and Functional Consequences of Age-Related Isomerization in α-Crystallins

2018-07-08

Abstract excerpt

Long-lived proteins are subject to spontaneous degradation and may accumulate a range of modifications over time, including subtle alterations such as isomerization. Recently, tandem-mass spectrometry approaches have enabled the identification and detailed characterization of such peptide isomers, including those differing only in chirality. However, the structural and functional consequences of these perturbation...

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Literature Corpus work: bf0334ac-a3b0-5aba-b25a-610cc2d57efd
DOI: 10.1101/364497

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