Article

A Disease-Associated Mutation Impedes PPIA Through Allosteric Dynamics Modulation

2025-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron degeneration. Peptidylprolyl cis-trans isomerase A (PPIA) is a molecular chaperone involved in protein folding, and its dysfunction has been linked to ALS pathogenesis as proline is recognized as a key residue for maintaining proper folding of ALS-related proteins. A recent study identif...

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Literature Corpus work: 3b045281-8301-5cfc-a0ca-0d7b39dda75c
DOI: 10.1101/2025.05.09.653011

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