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An Antioxidant Cocktail of Tert-Butylhydroquinone and a Manganese Porphyrin Induces Toxic Levels of Oxidative Stress in Cancer Cells

2025-12-19

Abstract excerpt

Despite significant advancement in cancer treatments, therapies with minimal toxicity to healthy cells are still limited. One targetable weakness of cancer cells is their sensitivity to oxidative stress. We find that the combination of two antioxidants—the common food additive tert-butylhydroquinone (tBHQ) and a manganese porphyrin in clinical trials, MnTnBuOE-2-PyP5+—increases oxidative stress and causes apoptoti...

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Literature Corpus work: cd8541a2-3f15-5da2-9aa6-13b16479585a
DOI: 10.20944/preprints202512.1737.v1

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