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Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells

9 Nov 2021

Abstract excerpt

Abstract Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial injury, leading to impaired cellular functions and cell death. Whether oxidative stress‐mediated telomere erosion induces mitochondrial injury, or vice versa, in human T cells—the major effectors of host adaptive immunity against infection and malignancy—is poorly understood due to the...

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Share to Cytomegalovirus and herpesvirus research
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 34752684
DOI: 10.1111/acel.13513

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