Article

Targeting Cancer with Redox Catalysis: Manganese Porphyrins and Ascorbate Synergistically Induce Selective Oxidative Stress and Necrotic Cell Death

2025-10-31

Abstract excerpt

<h4>Background: </h4> The combination of manganese porphyrins (MnPs) and ascorbate (ASC) represents a promising redox-based therapeutic approach for selectively targeting cancer cells. In this study, we investigated the cytotoxic effects of two structurally distinct MnPs (MnTPPS and MnF₂BMet) with differing lipophilicity and potential membrane permeability in combination with ASC. <h4>Methods:</h4> Human cancer ce...

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Literature Corpus work: 69714cd3-cedb-5a66-9363-219ad7a7f06d
DOI: 10.20944/preprints202510.2469.v1

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