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Third row transition metals for the treatment of cancer

10 Feb 2015

Abstract excerpt

Platinum compounds are a mainstay of cancer chemotherapy, with over 50% of patients receiving platinum. But there is a great need for improvement. Major features of the cisplatin mechanism of action involve cancer cell entry, formation mainly of intrastrand cross-links that bend and unwind nuclear DNA, transcription inhibition and induction of cell-death programmes while evading repair. Recently, we discovered...

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PMID: 25666060
DOI: 10.1098/rsta.2014.0185

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