Article
Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
Nature - 13 Jul 2011
Raj Lakshmi, Ide Takao, Gurkar Aditi U, Foley Michael, Schenone Monica, Li Xiaoyu, Tolliday Nicola J, Golub Todd R, Carr Steven A, Shamji Alykhan F, Stern Andrew M, Mandinova Anna, Schreiber Stuart L, Lee Sam W
Abstract excerpt
Malignant transformation, driven by gain-of-function mutations in oncogenes and loss-of-function mutations in tumour suppressor genes, results in cell deregulation that is frequently associated with enhanced cellular stress (for example, oxidative, replicative, metabolic and proteotoxic stress, and DNA damage). Adaptation to this stress phenotype is required for cancer cells to survive, and consequently cancer...
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