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Article

Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction

26 Aug 2019

Abstract excerpt

Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer. Mitochondria are an important source of ROS; however, the spatiotemporal ROS events underlying oxidative cellular damage from dysfunctional mitochondria remain unresolved. To this end, we have developed and validated a chemoptogenetic approach that uses a mitochondrially targeted fluorogen-activating peptide (Mito-FAP) to...

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PMID: 31451640
DOI: 10.1073/pnas.1910574116

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