Article

Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal Muscle

2024-05-31

Abstract excerpt

<title>Abstract</title> <p>The capacity to regenerate skeletal muscle function after injury requires a complex and well-coordinated cellular response, which is challenged in aged skeletal muscle. Here, we unravel the intricate dynamics of elderly human skeletal muscle regeneration by combining spatial, temporal, and single cell transcriptomics. Using spatial RNA sequencing, we profiled the expression of human pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd59e5da-8c20-5150-a948-570280f37b86
DOI: 10.21203/rs.3.rs-4471420/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal MuscleDOI 10.21203/rs.3.rs-4471420/v1Read

Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscleSemantic proximity Read

Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal MuscleSemantic proximity Read

Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cellsSemantic proximity Read

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosisSemantic proximity Read

Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and DiseasesSemantic proximity Read

Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF / MET Signaling‐Mediated Skeletal Muscle Stem Cell ProliferationSemantic proximity Read

Distinct human stem cell subpopulations drive adipogenesis and fibrosis in musculoskeletal injurySemantic proximity Read

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosisSemantic proximity Read

Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architectureSemantic proximity Read

The central role of macrophages in skeletal muscle regeneration: Phenotypic Polarization, metabolic reprogramming, and therapeutic prospects.Semantic proximity Read

A high-resolution single-nucleus RNA sequencing reveals conserved macrophage activation trajectories across muscle regeneration and dystrophy.Semantic proximity Read

Adipose tissue is a source of fibro-adipogenic progenitors for regenerating skeletal musclesSemantic proximity Read