Article

Distinct human stem cell subpopulations drive adipogenesis and fibrosis in musculoskeletal injury

2023-07-29

Abstract excerpt

Fibroadipogenic progenitors (FAPs) maintain healthy skeletal muscle in homeostasis but drive muscle degeneration in chronic injuries by promoting adipogenesis and fibrosis. To uncover how these stem cells switch from a pro-regenerative to pro-degenerative role we perform single-cell mRNA sequencing of human FAPs from healthy and injured human muscles across a spectrum of injury, focusing on rotator cuff tears. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3750a34f-9e32-5f23-94d9-9794a5e435bb
DOI: 10.1101/2023.07.28.551038

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct human stem cell subpopulations drive adipogenesis and fibrosis in musculoskeletal injuryDOI 10.1101/2023.07.28.551038Read

Rotator Cuff Tear Size Regulates Fibroadipogenic Progenitor Number and Gene Expression Profile in the Supraspinatus Independent of Patient AgeSemantic proximity Read

Single cell RNA sequencing of human FAPs reveals different functional stages in Duchenne muscular dystrophySemantic proximity Read

Muscle fibro-adipogenic progenitors from a single-cell perspective: Focus on their “virtual” secretomeSemantic proximity Read

Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitionsSemantic proximity Read

Muscle-Derived Beige Adipose Precursors Secrete Promyogenic Exosomes That Treat Rotator Cuff Muscle Degeneration in Mice and Are Identified in Humans by Single-Cell RNA SequencingSemantic proximity Read

Adipose tissue is a source of fibro-adipogenic progenitors for regenerating skeletal musclesSemantic proximity Read

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populationsSemantic proximity Read

Single-cell transcriptional profiles in human skeletal muscleSemantic proximity Read

Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal MuscleSemantic proximity Read

Mechanisms of cooperative cell-cell interactions in skeletal muscle regenerationSemantic proximity Read

Aberrant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced FibrosisSemantic proximity Read

Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscleSemantic proximity Read