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Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF / MET Signaling‐Mediated Skeletal Muscle Stem Cell Proliferation

25 Mar 2025

Abstract excerpt

Macrophages are key regulators of skeletal muscle regeneration, yet the specific macrophage subpopulations responsible for this process and their cell-cell interactions remain insufficiently understood, as does the mechanism underlying age-related impairment of skeletal muscle regeneration. We utilized single-cell RNA sequencing to identify transcriptionally distinct macrophage subpopulations within skeletal...

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PMID: 40132988
DOI: 10.1111/acel.70042

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