Article

A method for identifying genetic heterogeneity within phenotypically-defined disease subgroups

2016-01-22

Abstract excerpt

Many common diseases show wide phenotypic variation. We present a statistical method for determining whether phenotypically defined subgroups of disease cases represent different genetic architectures, in which disease-associated variants have different effect sizes in the two subgroups. Our method models the genome-wide distributions of genetic association statistics with mixture Gaussians. We apply a global test...

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Literature Corpus work: cd4be183-b382-598f-9afa-6ec322bc0321
DOI: 10.1101/037713

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