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Article

A method for identifying genetic heterogeneity within phenotypically defined disease subgroups.

Nature genetics - 1 Feb 2017

Liley James, Todd John A, Wallace Chris

Abstract excerpt

Many common diseases show wide phenotypic variation. We present a statistical method for determining whether phenotypically defined subgroups of disease cases represent different genetic architectures, in which disease-associated variants have different effect sizes in two subgroups. Our method models the genome-wide distributions of genetic association statistics with mixture Gaussians. We apply a global test...

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Share to Diabetes Mellitus, Type 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28024155
DOI: 10.1038/ng.3751
PMCID: PMC5357574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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