Article
A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice.
Blood - 1 Oct 2003
van Rijn Rozemarijn S, Simonetti Elles R, Hagenbeek Anton, Hogenes Marieke C H, de Weger Roel A, Canninga-van Dijk Marijke R, Weijer Kees, Spits Hergen, Storm Gert, van Bloois Louis, Rijkers Ger, Martens Anton C M, Ebeling Saskia B
Abstract excerpt
The safe application of new strategies for the treatment of graft-versus-host disease (GVHD) is hampered by the lack of a clinically relevant model for preclinical testing. Current models are based on intraperitoneal transfer of human peripheral blood mononuclear cells (huPBMCs) into NOD-SCID (nonobese diabetic-severe combined immunodeficient)/SCID mice. Intravenous transfer would be preferred but this has always...
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