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Article

A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells

24 Mar 2020

Abstract excerpt

In human-to-mouse xenogeneic transplantation, polymorphisms of signal-regulatory protein α (SIRPA) that decide their binding affinity for human CD47 are critical for engraftment efficiency of human cells. In this study, we generated a new C57BL/6.Rag2nullIl2rgnull (BRG) mouse line with Sirpahuman/human (BRGShuman) mice, in which mouse Sirpa was replaced by human SIRPA encompassing all 8 exons. Macrophages from...

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PMID: 32206775
DOI: 10.1182/blood.2019002194

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