Article

Glycated alpha-synuclein assemblies cause distinct Parkinson’s disease pathogenesis in mice

2025-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-synuclein (α-Syn) misfolding and aggregation are key drivers of Parkinson’s disease (PD) pathology. Mutations and certain post-translational modifications impact its aggregation propensity and pathogenicity. Glycation, a non-enzymatic modification enhanced during hyperglycemia and aging, both known risk factors for PD, has been implicated in α-Syn pathology. Although preformed α-Syn-fibril...

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Literature Corpus work: e5478fdc-6291-5b7c-b670-88bce58ac499
DOI: 10.1101/2025.06.04.657879

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