Article

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of mitochondrial LONP1

2022-09-13

Abstract excerpt

<h4>Summary</h4> Acute myeloid leukemia (AML) is an aggressive cancer with very poor outcomes. To identify additional drivers of leukemogenesis, we analyzed sequence data from 1,727 unique individual AML patients, which revealed mutations in ubiquitin ligase family genes in 11.2% of adult AML samples with mutual exclusivity. The Skp1/Cul1/Fbox (SCF) E3 ubiquitin ligase complex gene FBXO11 was the most significan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4dd19c75-5c28-567c-ba5d-4bf35cf42f47
DOI: 10.1101/2022.09.10.507366

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of mitochondrial LONP1DOI 10.1101/2022.09.10.507366Read

Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemiaSemantic proximity Read

Loss of FBXO9 enhances proteasome activity and promotes aggressiveness in acute myeloid leukemiaSemantic proximity Read

A two-step <i>in vivo</i> CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic targetSemantic proximity Read

In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic TargetSemantic proximity Read

Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemiaSemantic proximity Read

Mitophagy-Driven Prognosis in Pediatric Acute Myeloid Leukemia: A New FrontierSemantic proximity Read

Mutant ASXL1 Drives Transcriptional Activation and Repression in Human HematopoiesisSemantic proximity Read

FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndromeSemantic proximity Read

FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemiaSemantic proximity Read

Role of ASXL1 in hematopoiesis and myeloid diseases.Semantic proximity Read

UBA1 dysfunction in VEXAS and cancer.Semantic proximity Read

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.Semantic proximity Read