Article
Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML.
Blood - 28 Jul 2011
Payne Elspeth M, Bolli Niccolò, Rhodes Jennifer, Abdel-Wahab Omar I, Levine Ross, Hedvat Cyrus V, Stone Richard, Khanna-Gupta Arati, Sun Hong, Kanki John P, Gazda Hanna T, Beggs Alan H, Cotter Finbarr E, Look A Thomas
Abstract excerpt
In a zebrafish mutagenesis screen to identify genes essential for myelopoiesis, we identified an insertional allele hi1727, which disrupts the gene encoding RNA helicase dead-box 18 (Ddx18). Homozygous Ddx18 mutant embryos exhibit a profound loss of myeloid and erythroid cells along with cardiovascular abnormalities and reduced size. These mutants also display prominent apoptosis and a G1 cell-cycle arrest. Loss...
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