Article

ChemIntelligence Enables Antibody-Free, Ultra-Low-Input Profiling of Lysine Lactylation and Diverse Acyl-Proteomes

2026-08-31

Abstract excerpt

Lysine acylations, including lactylation (Klac), are pivotal regulators of cellular physiology. However, their analysis is currently bottlenecked by antibody enrichment strategies that suffer from sequence bias and require milligram-scale protein inputs, severely precluding the profiling of scarce clinical biopsies and rare cell populations. Here we present ChemIntelligence, an acyl-NHS chemistry-empowered derivat...

Identifiers and source

Literature Corpus work: d40dfe7c-4073-5e30-9af5-9c7d89feb9f3
DOI: 10.64898/2026.08.28.746934

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

ChemIntelligence Enables Antibody-Free, Ultra-Low-Input Profiling of Lysine Lactylation and Diverse Acyl-ProteomesDOI 10.64898/2026.08.28.746934Read

Reimagining proteome-wide evaluation of residue-specific bioconjugation chemistriesSemantic proximity Read

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics.Semantic proximity Read

Exploring the microbiome-wide lysine acetylation, succinylation and propionylation in human gut microbiotaSemantic proximity Read

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive argininesSemantic proximity Read

A curated human lactylome and protein language model framework enable accurate prediction and reveal local determinants of lysine lactylationSemantic proximity Read

Photoredox-catalyzed decarboxylative <i>C</i> -terminal differentiation for bulk and single molecule proteomicsSemantic proximity Read

A peptide-centric local stability assay to unveil protein targets of diverse ligandsSemantic proximity Read

Next-Generation Multiplexed Targeted Proteomics Quantifies Post-Translational Modifications, Compound-Protein Interactions, and Disease Biomarkers with High ThroughputSemantic proximity Read

An Unbiased Proteomic Platform for ATE1-based Arginylation ProfilingSemantic proximity Read

Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labelingSemantic proximity Read

A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAPSemantic proximity Read

A High-Quality Acetylation Dataset Reveals Modest Data Requirements for Transfer Learning to Identify Little Studied Post-Translational ModificationsSemantic proximity Read