Article

Nanopore dwell time analysis permits sequencing and conformational assignment of pseudouridine in SARS-CoV-2

2021-05-10

Abstract excerpt

Nanopore devices can directly sequence RNA, and the method has the potential to determine locations of epitranscriptomic modifications that have grown in significance because of their roles in cell regulation and stress response. Pseudouridine (Ψ), the most common modification in RNA, was sequenced with a nanopore system using a protein sensor with a helicase brake in synthetic RNAs with 100% modification at 18 kn...

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Literature Corpus work: cd122307-1527-5474-8ad8-eb4f1c9d2042
DOI: 10.1101/2021.05.10.443494

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