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The Evolution of Poxvirus Vaccines

7 Apr 2015

Abstract excerpt

After Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV), the causative agent of smallpox. Cowpox virus (CPXV) and horsepox virus (HSPV) were extensively used to this end, passaged in cattle and humans until the appearance of vaccinia virus (VACV), which was used in the final campaigns...

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PMID: 25853483
DOI: 10.3390/v7041726

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