Article

Optimization and deoptimization of codons in SARS-CoV-2 and the implications for vaccine development

2022-09-05

Abstract excerpt

<h4>ABSTRACT</h4> The spread of Coronavirus Disease 2019 (COVID-19), caused by the SARS-CoV-2 coronavirus, has progressed into a global pandemic. To date, thousands of genetic variants have been identified across SARS-CoV-2 isolates from patients. Sequence analysis reveals that the codon usage of viral sequences decreased over time but fluctuated from time to time. In this study, through evolution modeling, we fo...

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Literature Corpus work: 184dedab-2395-5486-b590-b9fdd8e91107
DOI: 10.1101/2022.09.03.506470

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