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Article

Influenza A Virus Attenuation by Codon Deoptimization of the NS Gene for Vaccine Development

26 Jun 2014

Abstract excerpt

UNLABELLED: Influenza viral infection represents a serious public health problem that causes contagious respiratory disease, which is most effectively prevented through vaccination to reduce transmission and future infection. The nonstructural (NS) gene of influenza A virus encodes an mRNA transcript that is alternatively spliced to express two viral proteins, the nonstructural protein 1 (NS1) and the nuclear...

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PMID: 24965472
DOI: 10.1128/jvi.01565-14

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