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The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis

14 Nov 2016

Abstract excerpt

Mouse oocytes respond to DNA damage by arresting in meiosis I through activity of the Spindle Assembly Checkpoint (SAC) and DNA Damage Response (DDR) pathways. It is currently not known if DNA damage is the primary trigger for arrest, or if the pathway is sensitive to levels of DNA damage experienced physiologically. Here, using follicular fluid from patients with the disease endometriosis, which affects 10% of...

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PMID: 27841311
DOI: 10.1038/srep36994

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