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The DNA Damage Response (DDR) landscape of endometrial cancer defines discrete disease subtypes and reveals therapeutic opportunities

2023-11-21

Abstract excerpt

Genome maintenance is an enabling characteristic that allows neoplastic cells to tolerate the inherent stresses of tumorigenesis and evade therapy-induced genotoxicity. Neoplastic cells also deploy mis-expressed germ cell proteins termed Cancer Testes Antigens (CTAs) to promote genome maintenance and survival. Here, we present the first comprehensive characterization of the DNA Damage Response (DDR) and CTA transc...

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Identifiers and source

Literature Corpus work
ee226232-2b4f-5cad-92ca-3568f4dcc227
DOI
10.1101/2023.11.20.567919
Open publication

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The DNA Damage Response (DDR) landscape of endometrial cancer defines discrete disease subtypes and reveals therapeutic opportunitiesDOI 10.1101/2023.11.20.567919
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