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Article

Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis.

BMC medicine - 15 Sept 2022

Shih Andrew J, Adelson Robert P, Vashistha Himanshu, Khalili Houman, Nayyar Ashima, Puran Radha, Herrera Rixsi, Chatterjee Prodyot K, Lee Annette T, Truskinovsky Alexander M, Elmaliki Kristine, DeFranco Margaret, Metz Christine N, Gregersen Peter K

Abstract excerpt

BACKGROUND: Endometriosis is a common, complex disorder which is underrecognized and subject to prolonged delays in diagnosis. It is accompanied by significant changes in the eutopic endometrial lining. METHODS: We have undertaken the first single-cell RNA-sequencing (scRNA-Seq) comparison of endometrial tissues in freshly collected menstrual effluent (ME) from 33 subjects, including confirmed endometriosis...

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Identifiers

PMID: 36104692
DOI: 10.1186/s12916-022-02500-3
PMCID: PMC9476391

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