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Two FAM134B isoforms differentially regulate ER dynamics during myogenesis

6 Jan 2025

Abstract excerpt

Endoplasmic reticulum (ER) plasticity and ER-phagy are intertwined processes essential for maintaining ER dynamics. We investigated the interplay between two isoforms of the ER-phagy receptor FAM134B in regulating ER remodeling in differentiating myoblasts. During myogenesis, the canonical FAM134B1 is degraded, while its isoform FAM134B2 is transcriptionally upregulated. The switch, favoring FAM134B2, is an...

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PMID: 39762646
DOI: 10.1038/s44318-024-00356-2

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