Article
Oncogenic RAS: From Its Activation to Its Direct Targeting.
Critical reviews in oncogenesis - 1 Jan 2017
Zaravinos Apostolos
Abstract excerpt
The RAS oncogenes are the most commonly mutated genes across human cancers. This review is a look back at the discovery of the RAS genes, how we came to understand their function, and how these oncogenes are aberrantly activated, driving cancer development and growth. It also highlights the comprehensive efforts made during the last 30 years to develop therapeutic strategies against the oncogenic mutant RAS....
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