Article

Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease

2023-09-29

Abstract excerpt

<h4>ABSTRACT</h4> We have witnessed three coronavirus (CoV) outbreaks in the past two decades, including the COVID-19 pandemic caused by SARS-CoV-2. Main protease (M Pro ) is a highly conserved and essential protease that plays key roles in viral replication and pathogenesis among various CoVs, representing one of the most attractive drug targets for antiviral drug development. Traditional antiviral drug develop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ccb326f0-c1ea-5632-a03f-7df9fa861ba7
DOI: 10.1101/2023.09.29.560163

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main ProteaseDOI 10.1101/2023.09.29.560163Read

Discovery of an Antiviral PROTAC Targeting the SARS-CoV-2 Main Protease Using an Allosteric WarheadSemantic proximity Read

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitorsSemantic proximity Read

Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19Semantic proximity Read

Identification of a Papain-Like Protease Inhibitor with Potential for Repurposing in Combination with an M <sup>pro</sup> Protease Inhibitor for Treatment of SARS-CoV-2Semantic proximity Read

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistanceSemantic proximity Read

Novel inhibitors against COVID-19 main protease suppressed viral infectionSemantic proximity Read

Targeted protein degraders of SARS-CoV-2 Mpro demonstrate superior antiviral activity over enzymatic inhibition alone and potency against nirmatrelvir resistant virusSemantic proximity Read

Structural basis for the inhibition of coronaviral main proteases by PF-00835231Semantic proximity Read

Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy.Semantic proximity Read

Structural basis for the inhibition of coronaviral main proteases by PF-00835231.Semantic proximity Read

Combating Antiviral Drug Resistance: A Multipronged Strategy.Semantic proximity Read

3-Chymotrypsin-like Protease (3CLpro): Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and Clinical TrialsSemantic proximity Read