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Article

Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy.

ACS combinatorial science - 8 Jun 2020

Goyal Bhupesh, Goyal Deepti

Abstract excerpt

A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a global health care emergency in the present time. The virus is referred to as SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) and has a genome similar (∼82%) to that of the previously known SARS-CoV (SARS coronavirus). An attractive therapeutic target for CoVs is the main protease (Mpro) or 3-chymotrypsin-like cysteine...

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Betacoronavirus
Coronavirus 3C Proteases
Coronavirus Infections
Cysteine Endopeptidases
Drug Discovery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pneumonia, Viral

Protease Inhibitors

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PMID: 32402186
DOI: 10.1021/acscombsci.0c00058

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