Article

Targeted protein degraders of SARS-CoV-2 Mpro demonstrate superior antiviral activity over enzymatic inhibition alone and potency against nirmatrelvir resistant virus

2024-11-25

Abstract excerpt

<title>Abstract</title> Targeted viral protein degraders, which enable physical elimination of viral protein target to inhibit all its primary and ancillary functions, could provide a new avenue to more effective antiviral drugs, overcoming the limitations associated with conventional inhibition-based direct-acting antiviral approaches, such as the selection of antiviral resistance. We have adapted SARS-CoV-2...

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Literature Corpus work: d974e8a3-64d2-554b-97b7-52b2428b19d5
DOI: 10.21203/rs.3.rs-3932156/v1

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