Article

Identification of a Papain-Like Protease Inhibitor with Potential for Repurposing in Combination with an M <sup>pro</sup> Protease Inhibitor for Treatment of SARS-CoV-2

2022-07-18

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 requires two cysteine proteases for viral polypeptide processing to allow maturation and replication: the 3C-like protease also known as the Main protease (M pro ) and the papain-like protease (PL pro ). In addition to its critical role in viral replication, PL pro removes post-translational modifications like ubiquitin and interferon-stimulated gene product 15 (ISG15) from host pr...

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Literature Corpus work: dcfd5578-b991-54a9-bfcd-827ddbf34277
DOI: 10.1101/2022.07.18.500363

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