Article

Matching or genetic engineering of HLA Class I and II facilitates successful allogeneic ‘off-the-shelf’ regulatory T cell therapy

2023-08-06

Abstract excerpt

The potential to harness regulatory T cells (Tregs) for the treatment of autoimmune diseases and transplant rejection has been restricted by several barriers: donor variability, manufacturing complications, and time-consuming expansion processes. These issues further complicate the use of autologous Tregs during acute disease phases or when Tregs are low in number or dysfunctional. Here we explore the potential of...

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Literature Corpus work: 3094fa6e-75ac-5b56-a119-6fd6ebacd47d
DOI: 10.1101/2023.08.06.551956

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