Article

Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis

2024-04-12

Abstract excerpt

Blood transfusion plays a vital role in modern medicine. However, availability is contingent on donated blood, and frequent shortages pose a significant healthcare challenge. Ex vivo manufacturing of red blood cells (RBCs) derived from universal donor O-negative pluripotent stem cells emerges as a solution, yet the high cost of recombinant cytokines required for ex vivo erythroid differentiation remains a major...

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Literature Corpus work: cc7005a2-c398-5880-bbd8-1117d36202ca
DOI: 10.1101/2024.04.12.589260

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