Article
Erythropoietin regulation of red blood cell production: from bench to bedside and back
2020-09-18
Abstract excerpt
More than 50 years of efforts to identify the major cytokine responsible for red blood cell (RBC) production (erythropoiesis) led to the identification of erythropoietin (EPO) in 1977 and its receptor (EPOR) in 1989, followed by three decades of rich scientific discovery. We now know that an elaborate oxygen-sensing mechanism regulates the production of EPO, which in turn promotes the maturation and survival of er...
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Identifiers and source
- Literature Corpus work
- 3227331c-4b19-5c05-bf4d-1880277c6a33
- DOI
- 10.12688/f1000research.26648.1