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Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies

26 Apr 2023

Abstract excerpt

Reactivation of fetal hemoglobin (HbF) is a commonly adapted strategy to ameliorate β-hemoglobinopathies. However, the continued production of defective adult hemoglobin (HbA) limits HbF tetramer production affecting the therapeutic benefits. Here, we evaluated deletional hereditary persistence of fetal hemoglobin (HPFH) mutations and identified an 11-kb sequence, encompassing putative repressor region (PRR) to...

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PMID: 37215154
DOI: 10.1016/j.omtn.2023.04.024

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