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The use of pluripotent stem cells to generate diagnostic tools for transfusion medicine.

Blood - 13 Oct 2022

An Hyun Hyung, Gagne Alyssa L, Maguire Jean Ann, Pavani Giulia, Abdulmalik Osheiza, Gadue Paul, French Deborah L, Westhoff Connie M, Chou Stella T

Abstract excerpt

Red blood cell (RBC) transfusion is one of the most common medical treatments, with more than 10 million units transfused per year in the United States alone. Alloimmunization to foreign Rh proteins (RhD and RhCE) on donor RBCs remains a challenge for transfusion effectiveness and safety. Alloantibody production disproportionately affects patients with sickle cell disease who frequently receive blood transfusions...

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Identifiers

PMID: 35977098
DOI: 10.1182/blood.2022015883
PMCID: PMC9707399

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