Article

A Study on the Aberrant Methylation of Colorectal Cancer MLH1 Gene

2019-01-01

Abstract excerpt

The aim of this paper is to study the mechanism of MLH1 gene expression and regulation in colorectal cancer, and to clarify the impact of 5' end CpG island aberrant methylation on the regulation of MLH1 gene expression. RT-PCR assay was used to detect the expression of MLH1 gene mRNA in 10 colon cancer cell strains. 62 fresh colorectal adenocarcinoma samples and paired distal normal mucosa were selected in our hos...

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Literature Corpus work: cc676a30-3f5b-5048-946e-e8f077945a05
DOI: 10.11648/j.ajcem.20190701.11

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