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Testing region selection and prognostic analysis of MLH1 promoter methylation in colorectal cancer in China

22 Dec 2023

Abstract excerpt

Abstract Background MLH1 promoter methylation analysis is recommended in screening for Lynch syndrome (LS) in patients with MLH1-deficient colorectal cancer (CRC). The study aims to identify specific methylation regions in the MLH1 promoter and to evaluate the clinicopathologic characteristics of and prognosis for patients with MLH1 methylation. Methods A total of 580 CRC cases were included. The DNA mismatch...

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PMID: 38566849
DOI: 10.1093/gastro/goae011

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