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Article

Spreading of Alu Methylation to the Promoter of the MLH1 Gene in Gastrointestinal Cancer

12 Oct 2011

Abstract excerpt

The highly repetitive Alu retroelements are regarded as methylation centres in the genome. Methylation in the gene promoters could be spreading from them. Promoter methylation of MLH1 is frequently detected in cancers, but the underlying mechanism is unclear. The aim of this study is to understand whether the methylation in the Alu elements is associated with promoter methylation in the MLH1 gene. Bisulfite...

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PMID: 22022465
DOI: 10.1371/journal.pone.0025913

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