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Article

Influenza Viruses with Rearranged Genomes as Live-Attenuated Vaccines

1 Mar 2013

Abstract excerpt

H5N1 and H9N2 avian influenza virus subtypes top the World Health Organization's list for the greatest pandemic potential. Inactivated H5N1 vaccines induce limited immune responses and, in the case of live-attenuated influenza virus vaccines (LAIV), there are safety concerns regarding the possibility of reassortment between the H5 gene segment and circulating influenza viruses. In order to overcome these...

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PMID: 23449800
DOI: 10.1128/jvi.02490-12

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