Article

Identification of the primary peptide inhibitor contaminant of fibrillation and toxicity in synthetic Amyloid-β42

2017-02-14

Abstract excerpt

Understanding the pathophysiology of Alzheimer disease has relied upon the use of amyloid peptides from a variety of sources, but most predominantly synthetic peptides produced using t-butyloxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc) chemistry. These synthetic methods can lead to minor impurities which can have profound effects on the biological activity of amyloid peptides. Here we used a combination o...

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Literature Corpus work: 9e93e86e-4112-531b-b0b4-793fb6709390
DOI: 10.1101/108563

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