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Article

Exposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagation

10 Dec 2024

Abstract excerpt

The dynamic balance between formation and disaggregation of amyloid fibrils is associated with many neurodegenerative diseases. Multiple chaperones interact with and disaggregate amyloid fibrils, which impacts amyloid propagation and cellular phenotypes. However, it remains poorly understood whether and how site-specific binding of chaperones to amyloids facilitates the concerted disaggregation process and...

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PMID: 39656207
DOI: 10.1073/pnas.2318162121

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Exposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagationPMID 39656207Read ↗

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