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Article

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers.

Science (New York, N.Y.) - 18 Jun 2004

Shorter James, Lindquist Susan

Abstract excerpt

The protein-remodeling factor Hsp104 governs inheritance of [PSI+], a yeast prion formed by self-perpetuating amyloid conformers of the translation termination factor Sup35. Perplexingly, either excess or insufficient Hsp104 eliminates [PSI+]. In vitro, at low concentrations, Hsp104 catalyzed the formation of oligomeric intermediates that proved critical for the nucleation of Sup 35 fibrillization de novo and...

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Identifiers

PMID: 15155912
DOI: 10.1126/science.1098007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers.PMID 15155912Read ↗

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