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Article

Dominant prion mutants induce curing through pathways that promote chaperone-mediated disaggregation.

Nature structural & molecular biology - 1 Apr 2011

DiSalvo Susanne, Derdowski Aaron, Pezza John A, Serio Tricia R

Abstract excerpt

Protein misfolding underlies many neurodegenerative diseases, including the transmissible spongiform encephalopathies (prion diseases). Although cells typically recognize and process misfolded proteins, prion proteins evade protective measures by forming stable, self-replicating aggregates. However, coexpression of dominant-negative prion mutants can overcome aggregate accumulation and disease progression through...

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PMID: 21423195
DOI: 10.1038/nsmb.2031
PMCID: PMC3082495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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