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Article

Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities.

Molecular cell - 4 Aug 2006

Shorter James, Lindquist Susan

Abstract excerpt

Yeast prions are protein-based genetic elements that self-perpetuate changes in protein conformation and function. A protein-remodeling factor, Hsp104, controls the inheritance of several yeast prions, including those formed by Sup35 and Ure2. Perplexingly, deletion of Hsp104 eliminates Sup35 and Ure2 prions, whereas overexpression of Hsp104 purges cells of Sup35 prions, but not Ure2 prions. Here, we used pure...

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Identifiers

PMID: 16885031
DOI: 10.1016/j.molcel.2006.05.042
PMCID: PMC1540446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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