Article

Segmentally duplicated regulatory elements undergo human-specific rewiring

2025-12-05

Abstract excerpt

Gene regulatory innovation underlies many phenotypic transitions. Transposable elements are an established mechanism for creating families of cis-acting elements with shared sequence features and the potential to establish co-regulatory networks. To understand additional mechanisms by which co-regulatory networks form, we define families of noncoding elements based on sequence similarity and cell type-specific act...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a56ee650-95b4-56d1-9510-9edf784343f1
DOI: 10.64898/2025.12.03.692127

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Segmentally duplicated regulatory elements undergo human-specific rewiringDOI 10.64898/2025.12.03.692127Read

Widespread Regulatory Turnover Across Human Segmental DuplicationsSemantic proximity Read

Influence of <i>cis</i> -regulatory elements on expression divergence in human segmental duplicationsSemantic proximity Read

Co-opted transposons help perpetuate conserved higher-order chromosomal structuresSemantic proximity Read

Transposable Element Mediated Innovation in Gene Regulatory Landscapes of Cells: Re-Visiting the "Gene-Battery" Model.Semantic proximity Read

Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cellsSemantic proximity Read

Regulatory Transposable Elements in the Encyclopedia of DNA ElementsSemantic proximity Read

Mechanistically Distinct Pathways of Divergent Regulatory DNA Creation Contribute to Evolution of Human-Specific Genomic Regulatory Networks Driving Phenotypic Divergence of Homo sapiens.Semantic proximity Read

Evolutionary rewiring of the human regulatory network by waves of genome expansionSemantic proximity Read

Transposable Elements and DNA Methylation Create in Embryonic Stem Cells Human-Specific Regulatory Sequences Associated with Distal Enhancers and Noncoding RNAs.Semantic proximity Read

Gene regulatory innovations from transposable elements in mammalian cerebellum developmentSemantic proximity Read

The Encyclopedia of DNA ElementsSemantic proximity Read

Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitorsSemantic proximity Read