Article

HIV and Cocaine exposure promote Tau phosphorylation through RSK-1 in a GSK3β-independent manner

2026-04-16

Abstract excerpt

HIV and cocaine are known to disrupt neuronal signaling and contribute to neurocognitive dysfunction, yet the underlying molecular mechanisms are not clear. In this study, we delineate the underlying molecular mechanism by which HIV and/or cocaine enhance Tau phosphorylation (p-Tau S396), a marker of Tau-mediated neuropathies. Furthermore, we elucidate how these two independent neuropathogenic factors, cocaine and...

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Literature Corpus work: cc0d81dc-0a54-5038-b195-c1e05c629c6b
DOI: 10.64898/2026.04.14.718541

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