Article

HIV and FIV glycoproteins increase cellular tau pathology via cGMP-dependent kinase II activation

2022-01-12

Abstract excerpt

As the development of combination antiretroviral therapy (cART) against human immunodeficiency virus (HIV) drastically improves the lifespan of individuals with HIV, many are now entering the prime age when Alzheimer’s disease (AD)-like symptoms begin to manifest. Hyperphosphorylated tau, a known AD pathological characteristic, has been prematurely increased in the brains of HIV-infected patients as early as in th...

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Literature Corpus work: cb601b86-d8e2-5259-93a2-fe330b68049d
DOI: 10.1101/2022.01.11.475910

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