Article

Spliceosomic profiling in pheochromocytomas and paragangliomas reveals alterations associated with clinico-molecular features and unveils RBM39 as a therapeutic target

2026-08-20

Abstract excerpt

<title>Abstract</title> <p> Pheochromocytomas (PCC) and paragangliomas (PGL), collectively termed PPGL, are neuroendocrine tumors with a high metastatic potential and limited treatment beyond surgery. Alternative splicing emerged as a key regulatory layer across most cancers; however, its relevance in PPGL remains unexplored. We performed a comprehensive characterization of splicing machinery across two independ...

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Literature Corpus work: c21fbb66-2513-5f46-831e-ff228bcbd77b
DOI: 10.21203/rs.3.rs-10679482/v1

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